PGT-A

Preimplantation Genetic Testing for Aneuploidy

What is PGT-A?

Pre implantation genetic testing for aneuploidy is a genetic test performed on biopsies of embryos being used for IVF. PGT-A is formerly known as PGS, pre implantation genetic screening.

PGT-A provides information about the number of chromosomes in an embryo to help your care team select the best embryo for transfer to improve odds of a successful pregnancy outcome.

Who is PGT-A for?

All couples are at risk to create embryos with extra or missing chromosome material (aneuploidy). This chance increases as women age. See statistics

Watch the video to see how PGT-A works

How PGT-A works

Chromosomes are the packages of genetic material that contain all of the DNA in the cells of the body. Usually, there are 46 chromosomes in each cell. Embryos with the usual number of chromosomes are called "euploid."

Sometimes, embryos are created with extra or missing chromosomes. These embryos are referred to as "aneuploid".

Aneuploid embryos are less likely to implant and more likely to end in miscarriage compared to euploid embryos. Embryos with extra or missing chromosome material can also lead to pregnancies with health problems including intellectual disability and birth defects.

Benefits of PGT-A

PGT-A has the potential to improve IVF outcomes in the following ways:

⦿ Increases implantation rates
⦿ Increases ongoing pregnancy rates
⦿ Increases confidence in single embryo transfer (SET)
⦿ Decreases miscarriage risks
⦿ Increases live birth rates
⦿ Reduces the time needed to achieve pregnancy

Preimplantation genetic testing of embryo health is extraordinary today.

We’re working to make
it ordinary tomorrow

Step 1. IVF

Embryos are produced through an IVF cycle.

Step 2. Embryo Biopsy

A small number of cells from the embryo are sent to Genomic Prediction Clinical Laboratory for analysis. Embryos are not shipped to our laboratory, we only need to examine the biopsy samples.

Step 3. Testing

The team at Genomic Prediction Clinical Laboratory carefully analyzes the genetic material present within each embryo biopsy sample.

Step 4. Reporting

A genetic report is issued to your care team so that you and your physician can select embryos for transfer that have the highest chance of a successful outcome.

Which disorders can your PGT-A test for?

WHOLE CHROMOSOME ANEUPLOIDY

PGT-A screening is designed to detect entire chromosomes that are added or missing. The term Trisomy refers to an extra chromosome. The term Monosomy refers to a missing chromosome.

SEGMENTAL ANEUPLOIDY

In addition to extra or missing whole chromosomes, PGT-A screening through our laboratory can detect extra or missing segments of chromosome material that are larger than 10Mb in size.

POLYPLOIDY

Polyploidy refers to an embryo with a whole extra set of chromosomes. Triploidy means there are three sets of chromosomes. Tetraploidy refers to anembryo with four sets of chromosomes. While polyploidy is a common cause of implantation failure and miscarriage, these types of chromosome anomalies are typically not seen following birth.

UNIPARENTAL DISOMY

Uniparental disomy or UPD refers to a set of chromosomes that were inherited from one parent instead of two. PGT-A screening through our laboratory can detect most forms of UPD.