PGT-M

Preimplantation Genetic Testing for Aneuploidy

What is PGT-M?

PGT-M, or pre implantation genetic testing for monogenic disorders, is for couples who have a higher chance of passing on a monogenic, or single gene, disorder. PGT-M was formerly known as PGD, pre implantation genetic diagnosis.

Every PGT-M test is unique and is specifically designed to address the genetic variants you are concerned about. Once testing is complete, embryos identified as unaffected for the tested condition are typically selected for transfer. This greatly reduces the chance of having an affected child.

Genomic Prediction Clinical Laboratory is able to address almost any genetic disease of concern. Your physician may refer you to discuss PGT-M if:

⦿ You have a pregnancy history or child who is diagnosed with a monogenic (single gene disorder).

⦿ You are carriers of the same autosomal recessive genetic condition.

⦿ One member of the couple is diagnosed with a genetic condition that is inherited in an autosomal dominant manner.

⦿ You are at risk of having a child with an X-linked inherited condition.

The vast majority of monogenic conditions can be addressed through PGT-M. We are available to review your genetic reports to determine the appropriate next steps in your case. PGT-M is highly accurate.

In most cases, studies can be completed with > 99% accuracy.

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PGT-M Benefits

How PGT-M works

How PGT-M works

STEP 1. REVIEW REPORTS

Genomic prediction clinical laboratory carefully reviews your genetic reports to determine the best way to proceed with testing.

STEP 2. GENETIC COUNSELING

The genetic counselor will review the benefits and limitations of PGT-SR testing. Parental saliva samples are collected (if possible) to aid the testing process.

STEP 3. IVF

Embryos are produced through an IVF cycle.

STEP 4. EMBRYO BIOPSY

The clinic carefully takes a small sample from each embryo. A small number of cells from the embryo are sent to Genomic Prediction Clinical Laboratory for analysis. Embryos are not shipped to our laboratory, we only need to examine the biopsy samples.

STEP 5. TESTING

The team at Genomic Prediction Clinical Laboratory carefully analyzes the genetic material present within each embryo biopsy sample.

STEP 6. REPORTING

A genetic report is issued to your care team so that you and your physician can select embryos for transfer that have the highest chance of a successful outcome.

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