PGT-SR
Preimplantation Genetic Testing for Aneuploidy
What is PGT-SR?
PGT-SR detects extra or missing chromosomal material related to a parental chromosome rearrangement. Individuals who carry a structural rearrangement have chromosomes arranged in a different order.
These rearrangements may increase the chance of fertility problems and miscarriage, and may lead to health problems following delivery.
Who is PGT-SR for?
PGT-SR is appropriate for individuals who have been identified as having a structural (chromosome) rearrangement by their physician.
There are different types of structural rearrangements including
RECIPROCAL TRANSLOCATIONS
A reciprocal translocation occurs when chromosome material from two different chromosomes switch places.
ROBERTSONIAN TRANSLOCATIONS
When two chromosomes attach together to form one larger chromosome, it is called a Robertsonian translocation. These type of chromosomes typically involve chromosomes 13, 14, 15, 21 and 22.
INVERSIONS
Inversions refer to a segment of chromosome material that is "flipped over."
DELETIONS
In which a segment of a chromosome is missing.
DUPLICATIONS
In which there is an extra segment of a chromosome.
STEP 1. REVIEW REPORTS
Genomic prediction clinical laboratory carefully reviews your genetic reports to determine the best way to proceed with testing.
How PGT-SR works
STEP 2. GENETIC COUNSELING
The genetic counselor will review the benefits and limitations of PGT-SR testing. Parental saliva samples are collected (if possible) to aid the testing process.
STEP 3. IVF
Embryos are produced through an IVF cycle.
STEP 4. EMBRYO BIOPSY
The clinic carefully takes a small sample from each embryo. A small number of cells from the embryo are sent to Genomic Prediction Clinical Laboratory for analysis. Embryos are not shipped to our laboratory, we only need to examine the biopsy samples.
STEP 5. TESTING
The team at Genomic Prediction Clinical Laboratory carefully analyzes the genetic material present within each embryo biopsy sample.
STEP 6. REPORTING
A genetic report is issued to your care team so that you and your physician can select embryos for transfer that have the highest chance of a successful outcome.
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